Hydrochloric Acid → 5-(2,2-Difluoroethoxy)-3-fluoro-pyridine-2-carboxylic acid
反応式
[OH-].[Na+].[F:3][CH:4]([F:19])[CH2:5][O:6][C:7]1[CH:8]=[C:9]([F:18])[C:10]([C:13]([O:15]CC)=[O:14])=[N:11][CH:12]=1.Cl.O1CCOCC1>C1COCC1>[F:19][CH:4]([F:3])[CH2:5][O:6][C:7]1[CH:8]=[C:9]([F:18])[C:10]([C:13]([OH:15])=[O:14])=[N:11][CH:12]=1参加物
6
実験手順
Sodium hydroxide (2 M in water, 2.43 mL, 4.86 mmol) is added to a solution of ethyl 5-(2,2-difluoroethoxy)-3-fluoro-pyridine-2-carboxylate (242 mg, 0.97 mmol) in THF (10 mL). The reaction is stirred at room temperature for 5 days. The reaction is quenched by the addition of 4 M HCl in dioxane (1.25 mL, 5 mmol) and the solution is concentrated to give the crude title compound (493 mg, 229%). ES/MS (m/e): 222.0 (M+1).
後処理
- concentrationthe solution is concentrated
出典と根拠
- ORDレコード
- ord-f612b36ab35a44d0a502314ac03ded05
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09029367B2
反応ノート
読み込み中…