Methyl iodide → HCID 178503348、化合物

HRID 573293

反応式

HRID 573293 の反応式
[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]1[SH:10].CI.[C:13]([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH3:13][S:10][C:2]1[NH:3][C:4]2=[N:5][CH:6]=[CH:7][CH:8]=[C:9]2[N:1]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178527819HCID 178527819、化合物

生成物 1

HCID 178503348HCID 178503348、化合物収率 22%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 1H-imidazo[4,5-b]pyridine-2-thiol (5.0 g) in acetone (75 mL) were added MeI (2.3 mL) and K2CO3 (18 g) at room temperature. After stirring for 1 day, the mixture was filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (1.2 g).

後処理

  1. filtrationthe mixture was filtered
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (AcOEt/hexane)

出典と根拠

ORDレコード
ord-83f8525bd2344d57981d3734115d833a
出典データセット
uspto-grants-2015_05
特許番号
US09029536B2

関連ノート

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