Piperidine → 2,3,4-Tris(octadecyloxy)benzhydryl amine

HRID 573967ノート

反応式

HRID 573967 の反応式
C1C2C(COC([NH:18][CH:19]([C:83]3[CH:88]=[CH:87][CH:86]=[CH:85][CH:84]=3)[C:20]3[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])=[C:22]([O:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH3:63])[C:21]=3[O:64][CH2:65][CH2:66][CH2:67][CH2:68][CH2:69][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH2:77][CH2:78][CH2:79][CH2:80][CH2:81][CH3:82])=O)C3C(=CC=CC=3)C=2C=CC=1.N1CCCCC1>C(Cl)(Cl)Cl.C(#N)C>[CH2:65]([O:64][C:21]1[C:22]([O:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH3:63])=[C:23]([O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH:24]=[CH:25][C:20]=1[CH:19]([NH2:18])[C:83]1[CH:88]=[CH:87][CH:86]=[CH:85][CH:84]=1)[CH2:66][CH2:67][CH2:68][CH2:69][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH2:77][CH2:78][CH2:79][CH2:80][CH2:81][CH3:82]

参加物

5

反応物 2

HCID 8082PiperidineHCID 59510359N-Fmoc-[phenyl(2,3,4-trioctadecanoxyphenyl)methyl]amine

生成物 1

HCID 469361412,3,4-Tris(octadecyloxy)benzhydryl amine収率 98%

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒HCID 6342Acetonitrile溶媒

実験手順

N-(9-Fluorenylmethoxycarbonyl)-2,3,4-tris(octadecyloxy)benzhydryl amine (3.37 g, 2.89 mmol) was dissolved in a mixed solvent of chloroform (30 mL) and acetonitrile (15 mL), 20% piperidine [1-methyl-2-pyrrolidone solution] (28.6 mL, 57.9 mmol) was added, and the mixture was stirred at room temperature for 30 min. After completion of the reaction, the reaction mixture was concentrated under reduced pressure, methanol was added, and the precipitated solid was collected by filtration. The obtained solid was dried under reduced pressure to give the title compound (2.80 g, 97.9%) as a white solid.

後処理

  1. additionwas added
  2. customAfter completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure, methanol
  4. additionwas added
  5. filtrationthe precipitated solid was collected by filtration
  6. customThe obtained solid was dried under reduced pressure

出典と根拠

ORDレコード
ord-f3fa4eab4f7f424d9c4f1615444d0221
出典データセット
uspto-grants-2015_05
特許番号
US09029528B2

反応ノート

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