Thionyl Chloride → 2-(Chloromethyl)-4H-1-benzopyran-4-one

HRID 574123ノート

反応式

HRID 574123 の反応式
O[CH2:2][C:3]1[O:4][C:5]2[C:10]([C:11](=[O:13])[CH:12]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[Cl:16][CH2:2][C:3]1[O:4][C:5]2[C:10]([C:11](=[O:13])[CH:12]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 12536095HCID 12536095、化合物

生成物 1

HCID 140019552-(Chloromethyl)-4H-1-benzopyran-4-one

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

The 2-(hydroxymethyl)-4H-chromen-4-one was dissolved in 30 ml of anhydrous chloroform at room temperature, 1 ml of thionyl chloride was added to the solution, and reaction mixture was stirred at room temperature for 24 hours. The solvent was thereafter evaporated, and the obtained liquid was dissolved in anhydrous hexane, which was also evaporated again to give 2-(chloromethyl)-4H-chromen-4-one which was further reacted without purification.

後処理

  1. customThe solvent was thereafter evaporated
  2. dissolutionthe obtained liquid was dissolved in anhydrous hexane
  3. customwhich was also evaporated again

出典と根拠

ORDレコード
ord-31677ca7dbbc4e74bc58de3ddaf5d14c
出典データセット
uspto-grants-2015_05
特許番号
US09034872B2

反応ノート

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