Water → 6-(Pyridin-2-yl)pyridazine-3-thiol
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10](=O)[NH:11][N:12]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:15].O>N1C=CC=CC=1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10](=[S:15])[NH:11][N:12]=1参加物
5
実験手順
500 mg (2.9 mmol) of pyridazinone 7 and 772 mg (3.5 mmol) of phosphorus pentasulfide are dissolved in 20 ml of anhydrous pyridine. The reaction mixture is brought to reflux for 18 h, and then cooled to ambient temperature. It is then poured into 200 ml of water, and the precipitate thus formed is filtered off and then washed with ice-cold water. The pyridazinethione 10 is obtained with a yield of 92%.
後処理
- temperatureto reflux for 18 h
- customthe precipitate thus formed
- filtrationis filtered off
- washwashed with ice-cold water
出典と根拠
- ORDレコード
- ord-ee53a89773d24a1ea64a87dac1a80651
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09034873B2
反応ノート
読み込み中…