N-methyl-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine → N2-methyl-N2-(tetrahydro-2H-pyran-4-yl)-2,5-Pyridinediamine

HRID 57550

反応式

HRID 57550 の反応式
[CH3:1][N:2]([CH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][N:4]=1>CO.[Pd]>[CH3:1][N:2]([CH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][N:4]=1

参加物

4

反応物 1

HCID 71113503N-methyl-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine

生成物 1

HCID 43610738N2-methyl-N2-(tetrahydro-2H-pyran-4-yl)-2,5-Pyridinediamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

反応条件

温度
20 °C

実験手順

To a solution of N-methyl-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine (217 mg, 0.92 mmol) in MeOH (30 mL) was added Pd/C (0.5 g). The mixture was stirred for 3 hours at 20° C. under 1 atm. H2. The reaction was filtered and concentrated to give dark red oil. MS (m/z): 208 (M+H)+

後処理

  1. filtrationThe reaction was filtered
  2. concentrationconcentrated
  3. customto give dark red oil

出典と根拠

ORDレコード
ord-3bdf9a7e1e4441f8bbbb21f22db9e522
出典データセット
uspto-grants-2016_09
特許番号
US09434726B2

関連ノート

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