Diisopropylethylamine → 6-((7-Chloropyrido[4,3-b]pyrazin-5-ylamino)methyl)morpholin-3-one
反応式
[NH2:1][CH2:2][CH:3]1[CH2:8][NH:7][C:6](=[O:9])[CH2:5][O:4]1.Cl[C:11]1[C:20]2[C:15](=[N:16][CH:17]=[CH:18][N:19]=2)[CH:14]=[C:13]([Cl:21])[N:12]=1.CCN(C(C)C)C(C)C>C1COCC1>[Cl:21][C:13]1[N:12]=[C:11]([NH:1][CH2:2][CH:3]2[CH2:8][NH:7][C:6](=[O:9])[CH2:5][O:4]2)[C:20]2[C:15](=[N:16][CH:17]=[CH:18][N:19]=2)[CH:14]=1参加物
5
実験手順
A solution of 6-(aminomethyl)morpholin-3-one (130 mg, 1 mmol), 5,7-dichloropyrido[4,3-b]pyrazine (200 mg, 1 mmol) and DIEA (260 mg, 2 mmol) in THF (20 mL) was stirred at reflux overnight. After concentration, the residue was purified by column chromatography to give product as yellow solid (100 mg).
後処理
- temperatureat reflux overnight
- concentrationAfter concentration
- customthe residue was purified by column chromatography
出典と根拠
- ORDレコード
- ord-6f6beef96c5c4616be22ff3013f6fbdc
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434726B2
反応ノート
読み込み中…