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Ammonium Chloride → 3-(7-Chloropyrido[4,3-b]pyrazin-5-ylamino)propanamide

HRID 57627
ノート
印刷プレビュー

反応式

HRID 57627 の反応式
[Cl:1][C:2]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][C:15]([OH:17])=O)[C:9]2[C:4](=[N:5][CH:6]=[CH:7][N:8]=2)[CH:3]=1.C[N:19](C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.[NH4+].[Cl-]>C1COCC1>[Cl:1][C:2]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][C:15]([NH2:19])=[O:17])[C:9]2[C:4](=[N:5][CH:6]=[CH:7][N:8]=2)[CH:3]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 25517Ammonium ChlorideHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 867173883-(7-Chloropyrido[4,3-b]pyrazin-5-ylamino)propanoic acid

生成物 1

HCID 867173893-(7-Chloropyrido[4,3-b]pyrazin-5-ylamino)propanamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 3-(7-chloropyrido[4,3-b]pyrazin-5-ylamino)propanoic acid (2.22 mmol), HATU (2.66 mmol), DIPEA (6.65 mmol) and NH4Cl (4.43 mmol) in THF (10 mL) was stirred at room temperature overnight. The volatiles were removed under reduced pressure and the residue was treated with water. The precipitates were collected by filtration and dried to give the title compound. MS (m/z): 252 (M+H)+.

後処理

  1. customThe volatiles were removed under reduced pressure
  2. additionthe residue was treated with water
  3. filtrationThe precipitates were collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-a8629fa55f2042d18372fb6dbcae1c48
出典データセット
uspto-grants-2016_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09434726B2

反応ノート

読み込み中…

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