Diisopropylethylamine → HCID 178499453、化合物

HRID 576659ノート

反応式

HRID 576659 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][N+:3]=1[O-:13].CCN(C(C)C)C(C)C.[NH2:23][CH2:24][CH2:25][NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30]>CC(O)(C)C>[C:29]([O:28][C:27]([NH:26][CH2:25][CH2:24][NH:23][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][N+:3]=1[O-:13])=[O:33])([CH3:32])([CH3:31])[CH3:30]

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 187201N-BOC-ethylenediamineHCID 59464117HCID 59464117、化合物

生成物 1

HCID 178499453HCID 178499453、化合物収率 32.2%

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

反応条件

温度
80 °C

実験手順

To 2-chloro-5-(2-methoxy-2-oxoethyl)pyridine 1-oxide (2.5 g) in t-BuOH (50 mL) was added DIEA (3.4 mL) and tert-butyl 2-aminoethylcarbamate (3.0 g). The resulting reaction mixture was stirred at 80° C. for 2 days. The solvent was then removed and the residue purified by reverse phase chromatography to afford the desired product (1.3 g).

後処理

  1. customThe resulting reaction mixture
  2. customThe solvent was then removed
  3. customthe residue purified by reverse phase chromatography

出典と根拠

ORDレコード
ord-9492210acb694b7d8711dd1f333c4dae
出典データセット
uspto-grants-2015_05
特許番号
US09040504B2

反応ノート

読み込み中…