Hydrogen Bromide → 1-Methyl-3-bromopropyldimethylamine hydrobromide

HRID 580114ノート

反応式

HRID 580114 の反応式
[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4]OC1C=CC=CC=1.[BrH:15]>C(Cl)(Cl)Cl>[BrH:15].[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4][Br:15]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 201358801-Methyl-3-phenoxypropyldimethylamine

生成物 1

HCID 201357911-Methyl-3-bromopropyldimethylamine hydrobromide収率 79%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

5 g of the 1-methyl-3-phenoxypropyldimethylamine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled and added with 20 ml of chloroform, and then the hydrobromic acid layer was separated from the chloroform layer. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.46 g of 1-methyl-3-bromopropyldimethylamine hydrobromide in a yield of 79%.

後処理

  1. temperatureThe reaction solution was cooled
  2. customthe hydrobromic acid layer was separated from the chloroform layer
  3. customThe hydrobromic acid was removed under reduced pressure
  4. customthe residue was recrystallized from 5 ml of ethyl alcohol

出典と根拠

ORDレコード
ord-e12a4395f1a244cb9caf87dd5864593f
出典データセット
uspto-grants-1988_06
特許番号
US04751302

反応ノート

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