Methanesulfonyl chloride → N-(5-Bromo-6-methyl-2-pyridinyl)methanesulfonamide

HRID 58038

反応式

HRID 58038 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:9])=[N:6][C:7]=1[CH3:8].C(N(C(C)C)C(C)C)C.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:9][S:20]([CH3:19])(=[O:22])=[O:21])=[N:6][C:7]=1[CH3:8]

参加物

5

反応物 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 1706782-Pyridinamine, 5-bromo-6-methyl-

生成物 1

HCID 79049128N-(5-Bromo-6-methyl-2-pyridinyl)methanesulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a mixture of 5-bromo-6-methylpyridin-2-amine (0.3 g, 1.604 mmol) and N-ethyl-N-isopropylpropan-2-amine (0.559 mL, 3.21 mmol) in DCM (10 mL) was added methanesulfonyl chloride (0.137 mL, 1.764 mmol) at 0° C. The reaction mixture was stirred at room temperature for 48 hours and was subsequently concentrated in vacuo to give the title compound.

後処理

  1. concentrationwas subsequently concentrated in vacuo

出典と根拠

ORDレコード
ord-eff90a1b5e1d49ba85eea4a95d9dbafd
出典データセット
uspto-grants-2016_09
特許番号
US09434743B2

関連ノート

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