Pyridine → N-(7-methoxy-1,8-naphthyridin2-yl)-3-acetoxybenzamide

HRID 580478

反応式

HRID 580478 の反応式
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[N:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1.[C:14]([O:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21](Cl)=[O:22])(=[O:16])[CH3:15].N1C=CC=CC=1>O>[CH3:13][O:12][C:6]1[N:5]=[C:4]2[C:9]([CH:10]=[CH:11][C:2]([NH:1][C:21](=[O:22])[C:20]3[CH:24]=[CH:25][CH:26]=[C:18]([O:17][C:14](=[O:16])[CH3:15])[CH:19]=3)=[N:3]2)=[CH:8][CH:7]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 129985583-(Chlorocarbonyl)phenyl acetateHCID 217930277-methoxy-1,8-Naphthyridin-2-amine

生成物 1

HCID 13983395N-(7-methoxy-1,8-naphthyridin2-yl)-3-acetoxybenzamide収率 78.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The procedure is similar to that described in Example 3, but starting with 2-amino-7-methoxynaphthyridine (3.5 g), 3-acetoxybenzoyl chloride (4.4 g) and anhydrous pyridine (40 cc). The reaction mixture is poured into water (400 cc) and the precipitate obtained is separated by filtration and then washed with water (6×100 cc) and dried in the air. On recrystallization from ethanol (140 cc) of the product thereby obtained, N-(7-methoxy-1,8-naphthyridin2-yl)-3-acetoxybenzamide (5.3 g), m.p. 172° C., is obtained.

後処理

  1. customthe precipitate obtained
  2. customis separated by filtration
  3. washwashed with water (6×100 cc)
  4. customdried in the air
  5. customOn recrystallization from ethanol (140 cc) of the product
  6. customthereby obtained

出典と根拠

ORDレコード
ord-2e02604d1e1447bfb7a6e3d9f54c6d2c
出典データセット
uspto-grants-1988_06
特許番号
US04753941

関連ノート

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