HCID 12130786、化合物 → 3-(Pyrimidin-4-yl)aniline

HRID 581918ノート

反応式

HRID 581918 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.C1COCC1.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 1

HCID 12130786HCID 12130786、化合物

生成物 1

HCID 124561713-(Pyrimidin-4-yl)aniline収率 96.1%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a suspension of (57) (6.3 g, 31 mmol) in a mixture of MeOH (60 ml) and THF (30 ml) was added 5% palladium on activated carbon (300 mg) and the mixture was hydrogenated at ambient pressure for 1 hr. The mixture was filtered and concentrated under reduced pressure. The residue was purified by column-chromatography on silica gel using a mixture of hexane and ethylacetate (3:1) as the eluent to give (58) (5.1 g, 96%).

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by column-chromatography on silica gel using
  4. additiona mixture of hexane and ethylacetate (3:1) as the eluent

出典と根拠

ORDレコード
ord-a5069e84f2b04ef59b17fbd933c68f11
出典データセット
uspto-grants-1999_07
特許番号
US05922725

反応ノート

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