Pyridine → S-n-hexadecyl p-nitrophenylthiocarbamate

HRID 583019ノート

反応式

HRID 583019 の反応式
[CH2:1]([SH:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[N+:18]([C:21]1[CH:26]=[CH:25][C:24]([N:27]=[C:28]=[O:29])=[CH:23][CH:22]=1)([O-:20])=[O:19].N1C=CC=CC=1>C(#N)C>[N+:18]([C:21]1[CH:22]=[CH:23][C:24]([NH:27][C:28](=[O:29])[S:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])=[CH:25][CH:26]=1)([O-:20])=[O:19]

参加物

5

反応物 3

HCID 1049PyridineHCID 18015HexadecanethiolHCID 66012Benzene, 1-isocyanato-4-nitro-

生成物 1

HCID 17762555S-n-hexadecyl p-nitrophenylthiocarbamate収率 97.1%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

In a three necked flask equipped with a dropping funnel, a thermometer and a reflux condenser, n-hexadecanethiol (165 g) was dissolved in acetonitrile (1000 ml). To the solution, p-nitrophenyl isocyanate (100 g) was gradually added, then pyridine (4 ml) was added dropwise, and the mixture was stirred at room temperature for 10 minutes, and then heat-refluxed for 30 minutes. When the reaction mixture was cooled to room temperature, crystals precipitated. The crystals were collected by filtering and washed with acetonitrile. S-n-hexadecyl p-nitrophenylthiocarbamate (250 g) was obtained at a yield of 97%.

後処理

  1. customIn a three necked flask equipped with a dropping funnel
  2. temperatureheat-refluxed for 30 minutes
  3. temperatureWhen the reaction mixture was cooled to room temperature
  4. customcrystals precipitated
  5. customThe crystals were collected
  6. filtrationby filtering
  7. washwashed with acetonitrile

出典と根拠

ORDレコード
ord-a29efbab1d0e4580a556cca9f7b2ef93
出典データセット
uspto-grants-1999_07
特許番号
US05928988

反応ノート

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