Pyridine → HCID 15220197、化合物

HRID 583049ノート

反応式

HRID 583049 の反応式
N1C=CC=CC=1.[CH:7]1([C:10](Cl)=[O:11])[CH2:9][CH2:8]1.[NH2:13][C:14]1[CH:15]=[C:16]([C:21]2[C:25]([Cl:26])=[C:24]([O:27][CH:28]([F:30])[F:29])[N:23]([CH3:31])[N:22]=2)[CH:17]=[CH:18][C:19]=1[Cl:20]>O1CCCC1>[Cl:26][C:25]1[C:21]([C:16]2[CH:17]=[CH:18][C:19]([Cl:20])=[C:14]([NH:13][C:10]([CH:7]3[CH2:9][CH2:8]3)=[O:11])[CH:15]=2)=[N:22][N:23]([CH3:31])[C:24]=1[O:27][CH:28]([F:30])[F:29]

参加物

5

反応物 3

HCID 1049PyridineHCID 77637Cyclopropanecarbonyl chlorideHCID 21226443HCID 21226443、化合物

生成物 1

HCID 15220197HCID 15220197、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

1.0 g (13 mmol) of pyridine and 0.7 g (6.5 mmol) of cyclopropanecarbonyl chloride were added to a solution of 2.0 g (6.5 mmol) of 3-(3-amino-4-chlorophenyl)-4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazole in 30 ml of tetrahydrofuran. The solution was stirred at room temperature overnight and at 50° C. for 2 hours, an then concentrated. The residue was taken up in ethyl acetate. The ethyl acetate was washed in succession with cold 1N hydrochloric acid, water and saturated sodium chloride solution, then dried over magnesium sulfate and finally concentrated. Yield: 2.2 g.

後処理

  1. concentrationan then concentrated
  2. washThe ethyl acetate was washed in succession with cold 1N hydrochloric acid, water and saturated sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. concentrationfinally concentrated

出典と根拠

ORDレコード
ord-0c3472d59bf94270b789077c1807dc69
出典データセット
uspto-grants-1999_07
特許番号
US05928999

反応ノート

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