Pyridine → 2-(((Trifluoromethyl)sulfonyl)oxy)acetic acid methyl ester

To a solution of triflic anhydride (3.7 ml, 20.0 nmmol) in methylene chloride (10 ml) at -5° C. under argon, was added dropwise over 30 minutes a solution of methyl glycolate (1.8 g, 20.0 mmol), pyridine (1.55 ml, 20.0 mmol), and anhydrous methylene chloride (5 ml). The reaction was allowed to stir at between 0°-5° C. for 1.5 h. The mixture was then washed with water several times. The organic extract was then washed with water, brine, and dried (MgSO4). After removing the solvent under reduced pressure, flash chromatography of the residue (silica gel, methylene chloride) afforded the title compound as a colorless oil (3.0 g, 68%).

1. washThe mixture was then washed with water several times
2. extractionThe organic extract
3. washwas then washed with water, brine
4. dry with materialdried (MgSO4)
5. customAfter removing the solvent under reduced pressure, flash chromatography of the residue (silica gel, methylene chloride)

ORDレコード

ord-9d9a450717f040f39685c3d8b5718813

出典データセット

uspto-grants-1999_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05929106