4-Aminopyrimidine → 2,2'-Dithiobis[N-4-pyrimidinyl benzamide]

HRID 583518

反応式

HRID 583518 の反応式
[C:1](Cl)(=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][S:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](Cl)=[O:13].[NH2:21][C:22]1[CH:27]=[CH:26][N:25]=[CH:24][N:23]=1>ClCCl.N1C=CC=CC=1>[N:25]1[CH:26]=[CH:27][C:22]([NH:21][C:1](=[O:19])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[S:8][S:9][C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([NH:21][C:22]2[CH:27]=[CH:26][N:25]=[CH:24][N:23]=2)=[O:13])=[N:23][CH:24]=1

参加物

5

反応物 2

HCID 689584-AminopyrimidineHCID 881642,2'-Dithiodibenzoyl chloride

生成物 1

HCID 215845632,2'-Dithiobis[N-4-pyrimidinyl benzamide]収率 2%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒

実験手順

This compound was prepared according to the general method of Example 90 using 2,2'-dithiobisbenzoyl chloride (3.00 g, 8.74 mmol) in 75 mL of dichloromethane and 4-aminopyrimidine (1.66 g, 17.5 mmol) in 14 mL of pyridine. The crude product was triturated with a hot mixture of acetonitrile and DMF, filtered, and recrystallized from water-DMF to yield 0.08 g of the title compound, mp 234-235° C.

後処理

  1. customThis compound was prepared
  2. customThe crude product was triturated with a hot mixture of acetonitrile and DMF
  3. filtrationfiltered
  4. customrecrystallized from water-DMF

出典と根拠

ORDレコード
ord-d881a339e814445cb42d203e19111e87
出典データセット
uspto-grants-1999_07
特許番号
US05929114

関連ノート

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