N-Iodosuccinimide → 2-n-Butyl-5-hydroxymethyl-4-iodoimidazole
反応式
[I:1]N1C(=O)CCC1=O.[CH2:9]([C:13]1[NH:14][CH:15]=[C:16]([CH2:18][OH:19])[N:17]=1)[CH2:10][CH2:11][CH3:12]>C(O)C.O>[CH2:9]([C:13]1[NH:17][C:16]([CH2:18][OH:19])=[C:15]([I:1])[N:14]=1)[CH2:10][CH2:11][CH3:12]参加物
5
反応条件
- 温度
- 42.5 °C
実験手順
N-Iodosuccinimide (148.75 g, 0.661 mol) was added to a stirred solution of 2-n-butyl-4-hydroxymethylimidazole (100.78 g, 0.652 mol) in 500 ml of absolute ethanol. After 20 minutes the solution was heated to 40-45° C. for 45 minutes, diluted with 2.5 L of water, and chilled. The crystalline product which formed was collected by filtration, washed with water, and dried to give 1.74.5 g (95%) of crystals; mp 166-166.5° C.
後処理
- temperaturechilled
- customThe crystalline product which formed
- filtrationwas collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-963353a592144156a5b116c9d881bf3b
- 出典データセット
- uspto-grants-1999_07
- 特許番号
- US05929249
反応ノート
読み込み中…