Tetrahydrofuran → 1,2-Dimethyl-1H-indol-5-amine
反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-])=O)=[CH:8][CH:9]=2)[CH:4]=[C:3]1[CH3:14].C1COCC1>[Pd].CO>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([NH2:11])=[CH:8][CH:9]=2)[CH:4]=[C:3]1[CH3:14]参加物
5
実験手順
A solution of 1,2-dimethyl-5-nitro-1H-indole (500 mg) in 1:1 THF:methanol (10 mL) was treated with 10% palladium on carbon (100 mg), stirred under hydrogen (1 atm) for 1 hour, filtered through diatomaceous earth (Celite®), and concentrated. The crude product was used without further purification in the next step.
後処理
- filtrationfiltered through diatomaceous earth (Celite®)
- concentrationconcentrated
- customThe crude product was used without further purification in the next step
出典と根拠
- ORDレコード
- ord-3252bf7833064e9e8f7cb876c88cd8b8
- 出典データセット
- uspto-grants-2005_08
- 特許番号
- US06924304B2
反応ノート
読み込み中…