Sodium Carbonate → HCID 178503197、化合物

HRID 584123ノート

反応式

HRID 584123 の反応式
Cl.[NH2:2][OH:3].C([O-])([O-])=O.[Na+].[Na+].[CH3:10][S:11][C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=1>O.CO>[OH:3][NH:2][C:16](=[NH:17])[C:15]1[CH:18]=[CH:19][C:12]([S:11][CH3:10])=[CH:13][CH:14]=1

参加物

6

反応物 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 5909604-(Methylthio)benzonitrile

生成物 1

HCID 178503197HCID 178503197、化合物収率 75%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

Hydroxylamine hydrochloride (104 mg, 1.5 mmol) and Na2CO3 (80 mg, 0.75 mmol) were dissolved in 0.5 mL of water. A solution of 4-methylsulfanyl-benzonitrile (223 mg, 1.5 mmol) in 4 mL of methanol was added and the combined solution was stirred at RT for about 48 h. After removal of the solvent, the precipitate was washed with water, filtered and dried to give N-hydroxy-4-methylsulfanyl-benzamidine (203 mg, 75%) which was used without further purification.

後処理

  1. customAfter removal of the solvent
  2. washthe precipitate was washed with water
  3. filtrationfiltered
  4. customdried

出典と根拠

ORDレコード
ord-039cdc46e35a4491b963e45525ae843a
出典データセット
uspto-grants-2005_08
特許番号
US06924284B2

反応ノート

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