Succinic anhydride → 3-[3-(4-Methylsulfanyl-phenyl)-[1,2,4]oxadiazol-5-yl]-propionic acid

HRID 584124

反応式

HRID 584124 の反応式
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.O[NH:9][C:10](=[NH:19])[C:11]1[CH:16]=[CH:15][C:14]([S:17][CH3:18])=[CH:13][CH:12]=1>CN(C=O)C>[CH3:18][S:17][C:14]1[CH:13]=[CH:12][C:11]([C:10]2[N:9]=[C:1]([CH2:2][CH2:3][C:4]([OH:6])=[O:5])[O:7][N:19]=2)=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 7922Succinic anhydrideHCID 178503197HCID 178503197、化合物

生成物 1

HCID 171222733-[3-(4-Methylsulfanyl-phenyl)-[1,2,4]oxadiazol-5-yl]-propionic acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
120 °C

実験手順

Succinic anhydride (112 mg, 1.12 mmol) and N-hydroxy-4-methylsulfanyl-benzamidine (203 mg, 1.12 mmol) were dissolved in 2.0 mL of DMF and heated at 120° C. overnight. The cooled solution was evaporated and dried to give 3-[3-(4-methylsulfanyl-phenyl)-[1,2,4]oxadiazol-5-yl]-propionic acid which was used without further purification.

後処理

  1. customThe cooled solution was evaporated
  2. customdried

出典と根拠

ORDレコード
ord-1c92a610d92b49ddaf94ad9316aee7bc
出典データセット
uspto-grants-2005_08
特許番号
US06924284B2

関連ノート

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