Sodium Carbonate → N-(2-(5-chloro-7-fluoro-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-5-(2,5-difluorobenzyl)isoxazole-3-carboxamide

反応式

[Cl:1][C:2]1[CH:8]=[C:7](I)[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[F:11][C:12]1[CH:37]=[CH:36][C:35]([F:38])=[CH:34][C:13]=1[CH2:14][C:15]1[O:19][N:18]=[C:17]([C:20]([NH:22][CH2:23][CH2:24][C:25]#[C:26][Si:27]([CH2:32][CH3:33])([CH2:30][CH3:31])[CH2:28][CH3:29])=[O:21])[CH:16]=1.[Cl-].[Li+].C(=O)([O-])[O-].[Na+].[Na+]>CN(C=O)C.[Cl-].[Na+].O.C1(P([C-]2C=CC=C2)C2C=CC=CC=2)C=CC=CC=1.[C-]1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=C1.[Fe+2].[Pd](Cl)Cl.C(OCC)(=O)C>[Cl:1][C:2]1[CH:8]=[C:7]2[C:5](=[C:4]([F:10])[CH:3]=1)[NH:6][C:26]([Si:27]([CH2:32][CH3:33])([CH2:30][CH3:31])[CH2:28][CH3:29])=[C:25]2[CH2:24][CH2:23][NH:22][C:20]([C:17]1[CH:16]=[C:15]([CH2:14][C:13]2[CH:34]=[C:35]([F:38])[CH:36]=[CH:37][C:12]=2[F:11])[O:19][N:18]=1)=[O:21]