Hydrazine hydrate (1:1) → HCID 90418397、化合物

HRID 588266

反応式

HRID 588266 の反応式
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:11]([O:13]C)=O)[CH:8]=2)[NH:3]1.O.[NH2:16][NH2:17]>CCO>[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:11]([NH:16][NH2:17])=[O:13])[CH:8]=2)[NH:3]1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 2773516Methyl 2,3-dihydro-2-oxo-1H-indole-5-carboxylate

生成物 1

HCID 90418397HCID 90418397、化合物収率 63%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a solution of methyl 2-oxoindoline-5-carboxylate (0.40 g, 4.8 mmol) in EtOH (8 ml) was added hydrazine monohydrate (2 ml), and the mixture was stirred for 6 h at 80° C. The mixture was cooled to room temperature, and the resulting precipitate was filtered and dried to afford 2-oxoindoline-5-carbohydrazide (0.25 g, 63%).

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe resulting precipitate was filtered
  3. customdried

出典と根拠

ORDレコード
ord-e5342dc332474d8a8f7145d33e1718e3
出典データセット
uspto-grants-2016_01
特許番号
US09227962B2

関連ノート

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