Sodium Iodide → HCID 90455791、化合物

HRID 588910ノート

反応式

HRID 588910 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]=[CH2:11].[Si]([C:16]([F:19])(F)[F:17])(C)(C)C.[Na+].[I-]>C1COCC1.CCCCCC>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]1[CH2:11][C:16]1([F:19])[F:17]

参加物

6

反応物 3

HCID 5238Sodium IodideHCID 552549(Trifluoromethyl)trimethylsilaneHCID 904560122-Chloro-4-methoxy-1-vinylbenzene

生成物 1

HCID 90455791HCID 90455791、化合物

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8058Hexane溶媒2 回

反応条件

温度
80 °C

実験手順

The solution of 2-chloro-4-methoxy-1-vinylbenzene (290 mg, 1.72 mmol) in dry THF (4 mL) was degassed, and then TMS-CF3 and NaI were added. The mixture was stirred at 80° C. overnight. TLC (100% Hexane) showed the reaction as complete. The mixture was diluted with hexane (20 mL). The inorganic salt was removed by filtration. The filtrate was concentrate in vacuo. The residue was purified via Isolera One (Hexane=100%).

後処理

  1. customthe reaction as complete
  2. customThe inorganic salt was removed by filtration
  3. concentrationThe filtrate was concentrate in vacuo
  4. customThe residue was purified via Isolera One (Hexane=100%)

出典と根拠

ORDレコード
ord-7a05b2e6b7874c4f9c5e1c48ee4d68dc
出典データセット
uspto-grants-2016_01
特許番号
US09227978B2

反応ノート

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