Hydrochloric Acid → HCID 178525248、化合物
反応式
[NH2:1][CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N+:13]([O-])=O)[CH2:3][C:4]([OH:6])=[O:5].Cl>[OH-].[Na+].O.NN.[Ni]>[NH:13]1[C:8]2[C:7](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:2]([CH2:3][C:4]([OH:6])=[O:5])=[N:1]1参加物
6
反応条件
- 温度
- 80 °C
実験手順
3-Amino-3-(2-nitrophenyl) propionic acid (15 g, 71.4 mmol) was dissolved in a mixed solution of 5% sodium hydroxide solution (85 mL) and 85% hydrazine hydrate (5 mL). The reaction was heated to 80° C., and then Raney nickel (2×25 mg) was added carefully. After reacted for half an hour, it was cooled, adjusted to pH≈2 with 6 N hydrochloric acid. A solid precipitated was pumping filtered, dried in vacuum to obtain a yellow solid 6.86 g, at a yield of 54.5%.
後処理
- customAfter reacted for half an hour
- temperatureit was cooled
- customA solid precipitated
- filtrationwas pumping filtered
- customdried in vacuum
出典と根拠
- ORDレコード
- ord-afa96c0cfc2c4fb8b6b2049654696ede
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09233098B2
反応ノート
読み込み中…