methyl 2-[1-(4-nitrobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]acetate → methyl 2-[1-(4-aminobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]acetate
反応式
[N+:1]([C:4]1[CH:24]=[CH:23][C:7]([CH2:8][N:9]2[C:13]3=[N:14][CH:15]=[CH:16][CH:17]=[C:12]3[C:11]([CH2:18][C:19]([O:21][CH3:22])=[O:20])=[N:10]2)=[CH:6][CH:5]=1)([O-])=O>O1CCCC1.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][N:9]2[C:13]3=[N:14][CH:15]=[CH:16][CH:17]=[C:12]3[C:11]([CH2:18][C:19]([O:21][CH3:22])=[O:20])=[N:10]2)=[CH:23][CH:24]=1参加物
4
実験手順
Methyl 2-[1-(4-nitrobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]acetate (75 mg, 0.23 mmol) was dissolved in 10 mL tetrahydrofuran. 10% Pd/C (5 mg) was added, and reacted under hydrogen atmosphere for 2 hours. It was filtered, and the filtrate was rotate evaporated to dryness directly to obtain a white solid 58 mg, at a yield of 87%.