Benzoyl Peroxide → 3-Bromo-2-(4-chlorobenzylidene)indan-1-one

HRID 59015

反応式

HRID 59015 の反応式
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH:6]=[C:7]2[CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]2=[O:16])=[CH:4][CH:3]=1.[Br:19]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:19][CH:15]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](=[O:16])[C:7]1=[CH:6][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:18][CH:17]=1

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 3672172-(p-Chlorobenzylidene)-1-indanone

生成物 1

HCID 687485823-Bromo-2-(4-chlorobenzylidene)indan-1-one

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

2-(4-chlorobenzylidene)indan-1-one (2.44 g, 9.58 mmol) was dissolved in 35 mL of CCl4. N-bromosuccinimide (1.685 g, 9.58 mmol) and benzoyl peroxide (122 mg, 0.52 mmol) were added in one portion. The solution was then stirred under reflux for one hour and then filtered once cooled to room temperature. The precipitate was separated using flash column chromatography (15:1 Hexanes/EtOAc) provided 14a as white crystals.

後処理

  1. temperatureunder reflux for one hour
  2. filtrationfiltered once
  3. customThe precipitate was separated

出典と根拠

ORDレコード
ord-814d39fdb22b4d17948eb2814524dcdd
出典データセット
uspto-grants-2016_09
特許番号
US09439877B2

関連ノート

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