Chlorobutanol → Methacrylic Acid

HRID 591115

反応式

HRID 591115 の反応式
[Cl:1][C:2]([Cl:8])([Cl:7])[C:3]([CH3:6])([OH:5])[CH3:4].[Cl:9][C:10]([CH3:16])([CH3:15])[C:11]([O:13][CH3:14])=[O:12]>CO>[C:11]([O:13][CH3:14])(=[O:12])[C:10]([CH3:16])=[CH2:15].[C:11]([OH:13])(=[O:12])[C:10]([CH3:16])=[CH2:15].[C:11]([O:5][C:3]([CH3:6])([CH3:4])[C:2]([Cl:8])([Cl:7])[Cl:1])(=[O:12])[C:10]([CH3:16])=[CH2:15].[Cl:9][C:10]([CH3:16])([CH3:15])[C:11]([O:5][C:3]([CH3:6])([CH3:4])[C:2]([Cl:8])([Cl:7])[Cl:1])=[O:12]

参加物

7

反応物 2

HCID 5977ChlorobutanolHCID 211144Methyl 2-chloro-2-methylpropanoate

生成物 4

HCID 4093Methacrylic AcidHCID 6658Methyl MethacrylateHCID 118163057(1,1,1-Trichloro-2-methyl-2-propyl) methacrylateHCID 118163068(1,1,1-Trichloro-2-methyl-2-propyl) 2-chloro-2-methylpropanoate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

To 2.83 g of the crude reaction solution obtained was added 0.11 g of methanol, followed by heating at 60° C. for 4 hours. Then, it was found out by gas chromatography analysis that the conversion of the 1,1,1-trichloro-2-methyl-2-propanol was 86.0% and the yield of methyl 2-chloro-2-methylpropanoate was 10.2%. As to other products, it was obtained methyl methacrylate in a 0.2% yield, methacrylic acid in a 8.7% yield, (1,1,1-trichloro-2-methyl-2-propyl) methacrylate in a 13.1% yield, and (1,1,1-trichloro-2-methyl-2-propyl) 2-chloro-2-methylpropanoate in a 22.8% yield.

後処理

  1. customTo 2.83 g of the crude reaction solution
  2. customobtained

出典と根拠

ORDレコード
ord-77e6c5fd78e34424b45ba1d920c490c3
出典データセット
uspto-grants-2016_01
特許番号
US09238612B2

関連ノート

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