Oxalyl chloride → 2-Chloro-6-fluorobenzoyl isocyanate

HRID 59236

反応式

HRID 59236 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:13](Cl)=[O:14]>C(Cl)CCl>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([N:6]=[C:13]=[O:14])=[O:5]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 985642-Chloro-6-fluorobenzamide

生成物 1

HCID 130517312-Chloro-6-fluorobenzoyl isocyanate収率 91,106.602%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

To a solution of 2-chloro-6-fluorobenzamide (2.0 g, 0.011 mmol) in EDC (10 mL) was added oxalyl chloride (2.18 g, 0.017 mmol). The reaction mass was refluxed for 24 h. Excess of solvent was removed under vacuum to afford 2.0 g of desired product.

後処理

  1. temperatureThe reaction mass was refluxed for 24 h
  2. customExcess of solvent was removed under vacuum

出典と根拠

ORDレコード
ord-4548ea085f674a4d899d467001b5b831
出典データセット
uspto-grants-2016_09
特許番号
US09439890B2

関連ノート

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