Boron trifluoride → 1-(4-(Trifluoromethyl)phenyl)cyclopropanamine

HRID 59248

反応式

HRID 59248 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1.[CH2:13]([Mg]Br)[CH3:14].B(F)(F)F>CC(C)[O-].[Ti+4].CC(C)[O-].CC(C)[O-].CC(C)[O-].C(OCC)C>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:10]=[CH:9][C:6]([C:7]2([NH2:8])[CH2:14][CH2:13]2)=[CH:5][CH:4]=1

参加物

6

反応物 3

HCID 6356Boron trifluorideHCID 67995Benzonitrile, 4-(trifluoromethyl)-HCID 178418443HCID 178418443、化合物

生成物 1

HCID 534204531-(4-(Trifluoromethyl)phenyl)cyclopropanamine収率 180%

試薬・触媒・溶媒 2

HCID 11026Titanium isopropoxide触媒HCID 3283Diethyl Ether溶媒

実験手順

The title compound was prepared according to the procedure described in Intermediate-12 by using of 4-(trifluoromethyl)benzonitrile (1.0 g, 0.58 mmol), diethyl ether (20 mL), titanium isopropoxide (2.0 g, 0.70 mmol), ethyl magnesium bromide (4.30 mL, 12.86 mmol) and boron trifluoride solution (1.5 mL) to afford 0.210 g of desired product. 1H NMR (CDCl3): δ 1.05 (s, 2H), 1.60 (s, 2H), 1.78 (s, 2H), 7.36 (d, J=7.8 Hz, 2H), 7.55 (d, J=8.1 Hz, 2H).

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-1907ea81c3484ddbbe15735aea810ce6
出典データセット
uspto-grants-2016_09
特許番号
US09439890B2

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