Ammonia → 4-Chloro-2-fluorobenzamide

HRID 59346

反応式

HRID 59346 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([F:11])[CH:3]=1.C(Cl)(=O)C(Cl)=O.[NH3:18]>C1COCC1>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:18])=[O:7])=[C:4]([F:11])[CH:3]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 65578Oxalyl chlorideHCID 991524-Chloro-2-fluorobenzoic acid

生成物 1

HCID 37218494-Chloro-2-fluorobenzamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 4-chloro-2-fluoro benzoic acid (1.5 g), THF (25 mL), oxalyl chloride (0.5 mL) and ammonia gas to afford 1.45 g of the product. 1H NMR (300 MHz, DMSO d6): δ 7.36 (d, J=6.3 Hz, H), 7.53 (dd, J=8.7 Hz, 1H), 7.64-7.76 (m, 3H).

出典と根拠

ORDレコード
ord-6720709cf12d4796b5bd8bb65a28f1bf
出典データセット
uspto-grants-2016_09
特許番号
US09439890B2

関連ノート

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