Ammonia → 3-((2,2,2-Trifluoroacetamido)methyl)-2,6-dimethylbenzamide

HRID 59354ノート

反応式

HRID 59354 の反応式
[F:1][C:2]([F:19])([F:18])[C:3]([NH:5][CH2:6][C:7]1[C:8]([CH3:17])=[C:9]([C:13]([CH3:16])=[CH:14][CH:15]=1)[C:10](O)=[O:11])=[O:4].C(Cl)(=O)C(Cl)=O.[NH3:26]>C1COCC1>[F:1][C:2]([F:19])([F:18])[C:3]([NH:5][CH2:6][C:7]1[C:8]([CH3:17])=[C:9]([C:13]([CH3:16])=[CH:14][CH:15]=1)[C:10]([NH2:26])=[O:11])=[O:4]

参加物

5

反応物 3

HCID 222AmmoniaHCID 65578Oxalyl chlorideHCID 866922272,6-Dimethyl-3-((2,2,2-trifluoroacetamido)methyl)benzoic acid

生成物 1

HCID 900191333-((2,2,2-Trifluoroacetamido)methyl)-2,6-dimethylbenzamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 3-((2,2,2-trifluoroacetamido)methyl)-2,6-dimethylbenzoic acid (1.0 g), oxalyl chloride (1.0 mL), THF (50 mL) and ammonia gas to afford 0.800 g of the desired product.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-af0e292915e14969a20ac42f8ad78e43
出典データセット
uspto-grants-2016_09
特許番号
US09439890B2

反応ノート

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