Hydrochloric Acid → 2-(Aminomethyl)-5-chloro-4-nitrobenzenamine

HRID 59378ノート

反応式

HRID 59378 の反応式
[NH2:1][C:2]1[CH:10]=[C:9]([Cl:11])[C:8]([N+:12]([O-:14])=[O:13])=[CH:7][C:3]=1[C:4]([NH2:6])=O.Cl.[OH-].[Na+]>C1COCC1>[NH2:6][CH2:4][C:3]1[CH:7]=[C:8]([N+:12]([O-:14])=[O:13])[C:9]([Cl:11])=[CH:10][C:2]=1[NH2:1]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 10751185HCID 10751185、化合物

生成物 1

HCID 900190742-(Aminomethyl)-5-chloro-4-nitrobenzenamine収率 72.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-amino-4-chloro-5-nitrobenzamide (3.0 g, 13.7 mmol) in dry THF (50 mL), borane dimethyl sulphide complex (1.56 g, 20.6 mmol) was added at RT and the reaction mass was refluxed for 24 h. The reaction mass was cooled to RT and dilute HCl was added till it became acidic. Further, the reaction mixture was stirred for 1 h and then the reaction mixture was basified with dilute NaOH and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous sodium sulphate and concentrated to afford 2.0 g of the desired product. 1H NMR (300 MHz, DMSO d6): δ 3.58 (s, 2H), 6.72 (br s, 3H), 8.04 (br s, 1H); MS (m/z): 200.28 (M−H).

後処理

  1. temperaturethe reaction mass was refluxed for 24 h
  2. extractionextracted with ethyl acetate
  3. customThe organic layer was separated
  4. dry with materialdried over anhydrous sodium sulphate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-9688e8207079452293aebd261d27162b
出典データセット
uspto-grants-2016_09
特許番号
US09439890B2

反応ノート

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