(2-Methylbenzo[d]thiazol-5-yl)methanol → 2-Methylbenzo[d]thiazole-5-carbaldehyde

HRID 594246ノート

反応式

HRID 594246 の反応式
[CH3:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][C:8]([CH2:11][OH:12])=[CH:7][C:5]=2[N:6]=1>C1COCC1.O=[Mn]=O>[CH3:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][C:8]([CH:11]=[O:12])=[CH:7][C:5]=2[N:6]=1

参加物

4

反応物 1

HCID 2341868(2-Methylbenzo[d]thiazol-5-yl)methanol

生成物 1

HCID 23088202-Methylbenzo[d]thiazole-5-carbaldehyde

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of (2-methylbenzo[d]thiazol-5-yl)methanol (400 mg; 2.23 mmol) in anh. THF (20 ml) was treated with MnO2 (3.026 g; 34.81 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 6.5 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with THF. The filtrate was concentrated to dryness under reduced pressure giving 2-methylbenzo[d]thiazole-5-carbaldehyde as a yellow solid. LC-MS (conditions B): tR=0.70 min.; [M+H]+: 178.03 g/mol.

後処理

  1. customThe resulting reaction mixture
  2. filtrationwas then filtered over celite
  3. washthe separated solids were washed with THF
  4. concentrationThe filtrate was concentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-b8cc8475964941f1978b92548ae3f5f3
出典データセット
uspto-grants-2016_01
特許番号
US09242970B2

反応ノート

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