Diethyl Oxalate → HCID 178473093、化合物

HRID 595042

反応式

HRID 595042 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[N:6][CH:7]=1.[C:11](OCC)(=[O:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13].[O-]CC.[Na+].CCCCCC>C1COCC1>[OH:17]/[C:11](=[CH:9]\[C:8]([C:4]1[CH:5]=[N:6][CH:7]=[C:2]([CH3:1])[CH:3]=1)=[O:10])/[C:12]([O:14][CH2:15][CH3:16])=[O:13]

参加物

6

反応物 4

HCID 7268Diethyl OxalateHCID 8058HexaneHCID 5775691-(5-Methylpyridin-3-yl)ethan-1-oneHCID 2723922Sodium ethoxide

生成物 1

HCID 178473093HCID 178473093、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
60 °C

実験手順

To a mixture of 1-2 (0.5 g, 3.70 mmol) and diethyl oxalate (1.010 ml, 7.40 mmol) in THF (15 ml) was added sodium ethoxide (3.45 ml, 21% wt. in ethanol, 9.25 mmol). The resulting mixture was heated at 60° C. for 1 h followed by stirring at rt overnight. The reaction mixture was poured into cold hexane and the desire product 1-3 was collected as a light yellow solid: ESI+ MS [M+H]+ C12H14NO4=236.1.

後処理

  1. customthe desire product 1-3 was collected as a light yellow solid

出典と根拠

ORDレコード
ord-0112dac7227f4bdc8ff4d33fb0395708
出典データセット
uspto-grants-2016_01
特許番号
US09242995B2

関連ノート

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