Chloroacetamide → 2-(3-Aminophenoxy)acetamide

HRID 596600ノート

反応式

HRID 596600 の反応式
[H-].[Na+].[OH:3][C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7].Cl[CH2:12][C:13]([NH2:15])=[O:14]>O>[NH2:7][C:6]1[CH:5]=[C:4]([CH:10]=[CH:9][CH:8]=1)[O:3][CH2:12][C:13]([NH2:15])=[O:14]

参加物

5

反応物 3

HCID 6580ChloroacetamideHCID 115683-AminophenolHCID 24758Sodium hydride2 回

生成物 1

HCID 104872522-(3-Aminophenoxy)acetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 50% sodium hydride (5.76 g., 0.12 M), 3-hydroxyaniline (13.09 g., 0.12 M) and chloroacetamide (11.22 g., 0.12 M) is stirred at room temperature for 18 hours. The mixture is diluted with water to decompose residual sodium hydride and is then extracted with chloroform. The chloroform extract is dried (MgSO4) and concentrated to an oil under reduced pressure. The addition of chloroform causes it to crystallize. Yield = 10.0g. (50%); m.p. 107°-111° C.

後処理

  1. extractionis then extracted with chloroform
  2. extractionThe chloroform extract
  3. dry with materialis dried (MgSO4)
  4. concentrationconcentrated to an oil under reduced pressure
  5. additionThe addition of chloroform
  6. customto crystallize

出典と根拠

ORDレコード
ord-2da4fd088a824536b4dbb61669342ccb
出典データセット
uspto-grants-1977_03
特許番号
US04011324

反応ノート

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