Water → 5-(3,7,11,15-Tetramethylhexadecyloxy)-2-furoic acid

HRID 596633

反応式

HRID 596633 の反応式
[CH3:1][CH:2]([CH2:6][CH2:7][CH2:8][CH:9]([CH3:21])[CH2:10][CH2:11][CH2:12][CH:13]([CH3:20])[CH2:14][CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:3][CH2:4][OH:5].[H-].[Na+].Cl[C:25]1[O:29][C:28]([C:30]([OH:32])=[O:31])=[CH:27][CH:26]=1.O>C1(C)C=CC=CC=1>[CH3:1][CH:2]([CH2:6][CH2:7][CH2:8][CH:9]([CH3:21])[CH2:10][CH2:11][CH2:12][CH:13]([CH3:20])[CH2:14][CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:3][CH2:4][O:5][C:25]1[O:29][C:28]([C:30]([OH:32])=[O:31])=[CH:27][CH:26]=1

参加物

6

反応物 4

HCID 962WaterHCID 24758Sodium hydrideHCID 102459DihydrophytolHCID 2348535-Chlorofuran-2-carboxylic acid

生成物 1

HCID 214504315-(3,7,11,15-Tetramethylhexadecyloxy)-2-furoic acid

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 59.8 g (0.2 mole) of 3,7,11,15-tetramethyl-1-hexadecanol and 19.2 g (0.4 mole) of sodium hydride (50% in oil) in 1 liter of toluene is refluxed with stirring for 2 hours then cooled to room temperature. To the mixture 29.3 g (0.2 mole) of 5-chloro-2-furoic acid is added and the mixture is refluxed with stirring for 24 hours. Upon cooling to room temperature the mixture is acidified with glacialacetic acid and water is added. The toluene layer is evaporated and allowed to crystallize to give 5-(3,7,11,15-tetramethylhexadecyloxy)-2-furoic acid.

後処理

  1. temperatureis refluxed
  2. temperaturethe mixture is refluxed
  3. stirringwith stirring for 24 hours
  4. temperatureUpon cooling to room temperature the mixture
  5. additionis added
  6. customThe toluene layer is evaporated
  7. customto crystallize

出典と根拠

ORDレコード
ord-fd13263df78048ae968f86bbe42ce2d6
出典データセット
uspto-grants-1977_03
特許番号
US04011334

関連ノート

読み込み中…