Thionyl Chloride → p-Tetradecyloxyphenylacetylchloride

HRID 596713

反応式

HRID 596713 の反応式
[CH2:1]([O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23]([OH:25])=O)=[CH:18][CH:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].S(Cl)([Cl:28])=O>C1C=CC=CC=1>[CH2:1]([O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23]([Cl:28])=[O:25])=[CH:18][CH:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 10472964p-Tetradecyloxyphenylacetic acid

生成物 1

HCID 10021844p-Tetradecyloxyphenylacetylchloride

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A solution of 10.0 g. p-tetradecyloxyphenylacetic acid in 100 ml. absolute benzene is treated with 19.9 g thionylchloride and refluxed for 2.5 hours. The reaction mixture is then evaporated under vacuum (i.v.) and azeotroped several times with benzene to remove residual thionylchloride, to obtain crude p-tetradecyloxyphenylacetylchloride, which may be used in Step E, below, without further refining.

後処理

  1. temperaturerefluxed for 2.5 hours
  2. customThe reaction mixture is then evaporated under vacuum (i.v.)
  3. customazeotroped several times with benzene
  4. customto remove residual thionylchloride

出典と根拠

ORDレコード
ord-5e97ab17b6eb4490a02e2bd78e3b8f55
出典データセット
uspto-grants-1977_03
特許番号
US04011339

関連ノート

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