Water → 2-Propenenitrile, 3-(4-fluorophenyl)-

HRID 596783

反応式

HRID 596783 の反応式
[F:1][C:2]1[CH:11]=[CH:10][C:5]([CH:6]=[CH:7][CH:8]=O)=[CH:4][CH:3]=1.C([O-])=O.[Na+].Cl.[NH2:17]O.O>C(O)=O>[F:1][C:2]1[CH:11]=[CH:10][C:5]([CH:6]=[CH:7][C:8]#[N:17])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 443297Hydroxyamine hydrochlorideHCID 2723810Sodium FormateHCID 533843793-(4-Fluorophenyl)-2-propenal

生成物 1

HCID 3673242-Propenenitrile, 3-(4-fluorophenyl)-収率 70.4%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

p-Fluorocinnamaldehyde (9.0 g.) was refluxed for 1 hr. in 98% formic acid containing sodium formate (10 g.) and hydroxylamine hydrochloride (7 g.). The solution was cooled and poured into water (275 ml.), giving a solid. This was washed well with water, leaving p-fluorocinnamonitrile (6.21 g., 70%), m.p. 64°-65°, λmax. (EtOH) 271 nm ε 22500.

後処理

  1. temperatureThe solution was cooled
  2. customgiving a solid
  3. washThis was washed well with water

出典と根拠

ORDレコード
ord-e9949bbebf3b423f8e3963e521514c62
出典データセット
uspto-grants-1977_03
特許番号
US04012377

関連ノート

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