3-Chloropropionitrile → 3-(3-Trifluoromethylphenylthio)-propionitrile

HRID 597392

反応式

HRID 597392 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([SH:9])[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+].Cl[CH2:15][CH2:16][C:17]#[N:18]>O>[F:11][C:2]([F:1])([F:10])[C:3]1[CH:4]=[C:5]([S:9][CH2:15][CH2:16][C:17]#[N:18])[CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 109633-ChloropropionitrileHCID 14798Sodium HydroxideHCID 1367513-(Trifluoromethyl)benzenethiol

生成物 1

HCID 198439363-(3-Trifluoromethylphenylthio)-propionitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 15.9 g (0.09 mol) of 3-trifluoromethylthiophenol and 3.8 g (0.095 mol) of sodium hydroxide pellets in 100 ml of water is heated at 65°-70° C and 8.5 g (0.095 mol) of β-chloropropionitrile are added dropwise whilst stirring. The mixture is heated for a quarter of an hour to the reflux temperature and is then cooled and extracted with ether, and the extract is washed with water and dried with magnesium sulphate. This gives 3-(3-trifluoromethylphenylthio)-propionitrile, which is not isolated.

後処理

  1. temperatureThe mixture is heated for a quarter of an hour to the reflux temperature
  2. temperatureis then cooled
  3. extractionextracted with ether
  4. washthe extract is washed with water
  5. dry with materialdried with magnesium sulphate

出典と根拠

ORDレコード
ord-56a53ea130574dc8acfa973d562739c3
出典データセット
uspto-grants-1977_03
特許番号
US04013776

関連ノート

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