3-Chloropropionitrile → 3-(3-Trifluoromethylphenylthio)-propionitrile
反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([SH:9])[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+].Cl[CH2:15][CH2:16][C:17]#[N:18]>O>[F:11][C:2]([F:1])([F:10])[C:3]1[CH:4]=[C:5]([S:9][CH2:15][CH2:16][C:17]#[N:18])[CH:6]=[CH:7][CH:8]=1参加物
5
実験手順
A solution of 15.9 g (0.09 mol) of 3-trifluoromethylthiophenol and 3.8 g (0.095 mol) of sodium hydroxide pellets in 100 ml of water is heated at 65°-70° C and 8.5 g (0.095 mol) of β-chloropropionitrile are added dropwise whilst stirring. The mixture is heated for a quarter of an hour to the reflux temperature and is then cooled and extracted with ether, and the extract is washed with water and dried with magnesium sulphate. This gives 3-(3-trifluoromethylphenylthio)-propionitrile, which is not isolated.
後処理
- temperatureThe mixture is heated for a quarter of an hour to the reflux temperature
- temperatureis then cooled
- extractionextracted with ether
- washthe extract is washed with water
- dry with materialdried with magnesium sulphate
出典と根拠
- ORDレコード
- ord-56a53ea130574dc8acfa973d562739c3
- 出典データセット
- uspto-grants-1977_03
- 特許番号
- US04013776
反応ノート
読み込み中…