Hydrazine hydrate (1:1) → 3,5-Diphenyl-4-methoxypyrazole

HRID 597584

反応式

HRID 597584 の反応式
CC(C(C1C=CC=CC=1)=O)=CC1C=CC=CC=1.O.NN.[C:21]1([C:27]2[NH:28][NH:29][CH:30]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:31]=2[O:32][CH3:33])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.N1CC=CN1>[Pd]>[C:21]1([C:27]2[C:31]([O:32][CH3:33])=[C:30]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)[NH:29][N:28]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

参加物

6

反応物 4

HCID 24654Hydrazine hydrate (1:1)HCID 99812alpha-MethylchalconeHCID 41560032,3-dihydro-1H-pyrazoleHCID 681174383,5-Diphenyl-4-methoxypyrazoline

生成物 1

HCID 124985213,5-Diphenyl-4-methoxypyrazole

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

Following the procedure of Example 1 but substituting α-methoxychalcone for α-methylchalcone, and reacting the same with hydrazine hydrate, there is prepared 3,5-diphenyl-4-methoxypyrazoline. The so-formed pyrazoline is then reacted with Pd/C at reflux to obtain 3,5-diphenyl-4-methoxypyrazole in good yield.

後処理

  1. temperatureat reflux

出典と根拠

ORDレコード
ord-f790a37f3f694e10be2af2feedb1248f
出典データセット
uspto-grants-1977_03
特許番号
US04014896

関連ノート

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