Potassium Carbonate → HCID 178509280、化合物

HRID 59789

反応式

HRID 59789 の反応式
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][CH2:7][N:8]([CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH2:9][CH2:10][NH:11][C:12](=[O:19])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].[C:34]([N:36]=[C:37]([N:39]1CCNCC1)[S-])#[N:35].O.[NH2:46]N>>[NH2:46][C:37]1[N:36]=[C:34]([N:23]2[CH2:22][CH2:21][CH:20]([N:8]([CH2:7][CH2:6][C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:27][CH:26]=3)[CH2:9][CH2:10][NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:25][CH2:24]2)[NH:35][N:39]=1

参加物

5

反応物 4

HCID 11430Potassium CarbonateHCID 24654Hydrazine hydrate (1:1)HCID 121410331N-(2-((4-chlorophenethyl)(piperidin-4-yl)amino)ethyl)benzamideHCID 131737066HCID 131737066、化合物

生成物 1

HCID 178509280HCID 178509280、化合物

実験手順

N-(2-((4-Chlorophenethyl)(piperidin-4-yl)amino)ethyl)benzamide obtained in Step 4 was reacted with K2CO3 and S,S′-dimethyl-N-cyano-dithioiminocarbonate, followed by the cyclization of the intermediate (N-cyanopiperazine-1-carbimidothioate) with hydrazine monohydrate in a manner described in Procedure 3. Purification over silica gel provided pure product.

後処理

  1. customPurification over silica gel provided pure product

出典と根拠

ORDレコード
ord-74267245d16542a2bcfaf4369e448bf8
出典データセット
uspto-grants-2016_09
特許番号
US09440953B2

関連ノート

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