Hydrochloric Acid → 5-(2,4-Dichlorophenyl)-3-methylpenta-2,4-dienoic acid
反応式
C([O:3][C:4](=[O:18])[CH:5]=[C:6]([CH3:17])[CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[Cl:16])C.CO.[OH-].[Na+].Cl>C1COCC1.O>[Cl:16][C:10]1[CH:11]=[C:12]([Cl:15])[CH:13]=[CH:14][C:9]=1[CH:8]=[CH:7][C:6]([CH3:17])=[CH:5][C:4]([OH:18])=[O:3]参加物
7
実験手順
5-(2,4-Dichlorophenyl)-3-methylpenta-2,4-dienoic acid ethyl ester (5 g, 0.0184 mol) was dissolved in THF (125 mL). Water (50 mL), MeOH (50 mL), and NaOH (18.44 mL of a 2M solution in water, 2 eq) were then added. After 6 hours, TLC analysis showed complete conversion of the starting materials and the mixture was acidified to pH 1 by addition of 6N HCl. The resulting solid was collected to give 4.24 g of 5-(2,4-dichlorophenyl)-3-methylpenta-2,4-dienoic acid.
後処理
- customThe resulting solid was collected
出典と根拠
- ORDレコード
- ord-9d0519cf18e14e2d8941badd9e5c80f1
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07897601B2
反応ノート
読み込み中…
