Sodium Hydroxide → HCID 136400718、化合物
反応式
[I:1][C:2]1[C:10]2[C:9](=[O:11])[NH:8][C:7]([NH:12]C(=O)C(C)(C)C)=[N:6][C:5]=2[N:4]([CH3:19])[CH:3]=1.[OH-].[Na+]>O1CCCC1>[NH2:12][C:7]1[NH:8][C:9](=[O:11])[C:10]2[C:2]([I:1])=[CH:3][N:4]([CH3:19])[C:5]=2[N:6]=1参加物
4
実験手順
To a solution of N-(5-iodo-7-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide (17.9 g, 47.8 mmol) in tetrahydrofuran (150 ml) was added 2N aqueous solution of sodium hydroxide (57.4 ml, 115 mmol) at 0° C., and the mixture was refluxed for 5 hours After cooling, the solvent was evaporated in vacuo. The suspension was neutralized with 1N hydrochloric acid, and the resulting crystals were collected by filtration and washed with water to give 13.3 g (96%) of the title compound.
後処理
- temperaturethe mixture was refluxed for 5 hours
- temperatureAfter cooling
- customthe solvent was evaporated in vacuo
- filtrationthe resulting crystals were collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-03f81af180f64f519f71862f2325fda5
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07897607B2
反応ノート
読み込み中…