Sodium hydride → HCID 178498783、化合物
反応式
Cl[C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][N:5]=[CH:4][C:3]=1[C:12]([O:14]C)=O.C(O)(=O)C.[CH:20](=[NH:22])[NH2:21].[H-].[Na+]>O1CCOCC1>[OH:14][C:12]1[C:3]2[CH:4]=[N:5][CH:6]=[C:7]([C:8]([O:10][CH3:11])=[O:9])[C:2]=2[N:21]=[CH:20][N:22]=1参加物
5
実験手順
To the mixture of dimethyl 4-chloropyridine-3,5-dicarboxylate (0.6 g, 2.6 mmol) and formimidamide acetate (0.82 g, 7.8 mmol) in dioxane (20 mL) was added NaH (0.31 g, 7.8 mmol). The resulting mixture was refluxed for 48 hours, cooled to RT. The precipitate was filtered, and washed with EA to afford the title compound as grey solid (yield 56.1%).
後処理
- temperatureThe resulting mixture was refluxed for 48 hours
- filtrationThe precipitate was filtered
- washwashed with EA
出典と根拠
- ORDレコード
- ord-d8e04bf101054bd485f02b6b7bb4af81
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09440968B2
反応ノート
読み込み中…