O-Phenylenediamine → 4-methyl-N-(2-{[(4-methylphenyl)sulfonyl]amino}phenyl)benzenesulfonamide

HRID 600612ノート

反応式

HRID 600612 の反応式
[C:1]1([NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH2:7].[C:9]1([CH3:19])[CH:14]=[CH:13][C:12]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:10]=1>N1C=CC=CC=1.ClCCl>[C:9]1([CH3:19])[CH:14]=[CH:13][C:12]([S:15]([NH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[NH:8][S:15]([C:12]2[CH:13]=[CH:14][C:9]([CH3:19])=[CH:10][CH:11]=2)(=[O:17])=[O:16])(=[O:17])=[O:16])=[CH:11][CH:10]=1

参加物

5

反応物 2

HCID 7243O-PhenylenediamineHCID 73974-Toluenesulfonyl chloride

生成物 1

HCID 2566074-methyl-N-(2-{[(4-methylphenyl)sulfonyl]amino}phenyl)benzenesulfonamide収率 95%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution in which 1,2-phenylenediamine (0.5 mmol) was dissolved in pyridine (1 mL) was added p-toluenesulfonyl chloride (1.1 mmol) at room temperature, and the mixture was reacted for 6 hours with stirring. After completion of the reaction, the reaction mixture was diluted with dichloromethane, and back extracted using 1N hydrochloric acid to remove pyridine. After the organic layer was dried with anhydrous sodium sulfate, and concentrated. The obtained solid was washed using diethyl ether on a Buchner funnel, and dried under reduced pressure to obtain an objective substance as a white solid in a yield of more than 95% yield.

後処理

  1. customthe mixture was reacted for 6 hours
  2. customAfter completion of the reaction
  3. extractionback extracted
  4. customto remove pyridine
  5. dry with materialAfter the organic layer was dried with anhydrous sodium sulfate
  6. concentrationconcentrated
  7. washThe obtained solid was washed
  8. customdried under reduced pressure
  9. customto obtain an objective substance as a white solid in a yield of more than 95% yield

出典と根拠

ORDレコード
ord-182c00aece274692ad92990c9752b7d6
出典データセット
uspto-grants-2011_03
特許番号
US07902207B2

反応ノート

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