Dimethylamine → N,N-dimethyl-6-nitropyridin-3-amine

HRID 600635

反応式

HRID 600635 の反応式
Br[C:2]1[CH:3]=[CH:4][C:5]([N+:8]([O-:10])=[O:9])=[N:6][CH:7]=1.[CH3:11][NH:12][CH3:13]>C(O)C.O1CCCC1>[CH3:11][N:12]([CH3:13])[C:2]1[CH:7]=[N:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 674DimethylamineHCID 8176205-Bromo-2-nitropyridine

生成物 1

HCID 21897368N,N-dimethyl-6-nitropyridin-3-amine

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
140 °C

実験手順

To a solution of 1 g of 5-bromo-2-nitropyridine in 5 mL of ethanol are added 6 mL of a 2 M solution of dimethylamine in tetrahydrofuran. The reaction mixture is heated for 2 hours at 140° C. in a microwave machine. After cooling, the solid formed is separated off and washed with ethyl ether to give 850 mg of N,N-dimethyl-6-nitropyridine-3-amine in the form of a yellow solid.

後処理

  1. temperatureAfter cooling
  2. customthe solid formed
  3. customis separated off
  4. washwashed with ethyl ether

出典と根拠

ORDレコード
ord-25afc96babc0498cbc402ec49c76ff41
出典データセット
uspto-grants-2011_03
特許番号
US07902219B2

関連ノート

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