Tetrahydrofuran → N-(2-methylcyclopentyl)-3,4-difluorobenzamide

HRID 602000

反応式

HRID 602000 の反応式
C1COCC1.[F:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=1[F:16])[C:10](Cl)=[O:11].Cl.[CH3:18][CH:19]1[CH2:23][CH2:22][CH2:21][CH:20]1[NH2:24].C(N(CC)CC)C>C(OCC)(=O)C>[CH3:18][CH:19]1[CH2:23][CH2:22][CH2:21][CH:20]1[NH:24][C:10](=[O:11])[C:9]1[CH:13]=[CH:14][C:15]([F:16])=[C:7]([F:6])[CH:8]=1

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 27245193,4-Difluorobenzoyl chlorideHCID 191014392-Methylcyclopentan-1-amine hydrochloride

生成物 1

HCID 57445707N-(2-methylcyclopentyl)-3,4-difluorobenzamide収率 84.3%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a mixture of 10 ml of THF and 0.60 g of 3,4-difluorobenzoyl chloride were added 0.37 g of 2-methylcyclopentylamine hydrochloride and 1.0 g of triethylamine, and the mixture obtained was stirred at room temperature for 3 hours. Then, ethyl acetate was added to the reaction mixture and filtered through Celite. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.55 g of N-(2-methylcyclopentyl)-3,4-difluorobenzamide.

後処理

  1. customthe mixture obtained
  2. filtrationfiltered through Celite
  3. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-8ab286347c77495d9716b68571a0fd09
出典データセット
uspto-grants-2011_03
特許番号
US07902400B2

関連ノート

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