Thionyl Chloride → 3-Methoxy-4-(2-propynyloxy)benzoyl chloride
反応式
[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[CH:7][C:6]=1[O:14][CH3:15])[C:2]#[CH:3].S(Cl)([Cl:18])=O>CN(C=O)C.C1(C)C=CC=CC=1>[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([Cl:18])=[O:10])=[CH:7][C:6]=1[O:14][CH3:15])[C:2]#[CH:3]参加物
5
実験手順
To 100 ml of toluene were added 12.0 g of 4-(2-propynyloxy)-3-methoxybenzoic acid, 9.0 g of thionyl chloride and 50 mg of DMF, and the mixture obtained was heated under reflux for 3 hours. Then, the reaction mixture was concentrated. The solid obtained was washed with hexane to obtain 11.0 g of 4-(2-propynyloxy)-3-methoxybenzoyl chloride represented by the formula.
後処理
- customthe mixture obtained
- temperaturewas heated
- temperatureunder reflux for 3 hours
- concentrationThen, the reaction mixture was concentrated
- customThe solid obtained
- washwas washed with hexane
出典と根拠
- ORDレコード
- ord-c4844b0198954552a6ae17f7c6d001e8
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07902400B2
反応ノート
読み込み中…