Thionyl Chloride → 3-Methoxy-4-(2-propynyloxy)benzoyl chloride

HRID 602015

反応式

HRID 602015 の反応式
[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[CH:7][C:6]=1[O:14][CH3:15])[C:2]#[CH:3].S(Cl)([Cl:18])=O>CN(C=O)C.C1(C)C=CC=CC=1>[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([Cl:18])=[O:10])=[CH:7][C:6]=1[O:14][CH3:15])[C:2]#[CH:3]

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 131214803-Methoxy-4-(prop-2-ynyloxy)benzoic acid

生成物 1

HCID 574456713-Methoxy-4-(2-propynyloxy)benzoyl chloride収率 84.1%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 1140Toluene溶媒

実験手順

To 100 ml of toluene were added 12.0 g of 4-(2-propynyloxy)-3-methoxybenzoic acid, 9.0 g of thionyl chloride and 50 mg of DMF, and the mixture obtained was heated under reflux for 3 hours. Then, the reaction mixture was concentrated. The solid obtained was washed with hexane to obtain 11.0 g of 4-(2-propynyloxy)-3-methoxybenzoyl chloride represented by the formula.

後処理

  1. customthe mixture obtained
  2. temperaturewas heated
  3. temperatureunder reflux for 3 hours
  4. concentrationThen, the reaction mixture was concentrated
  5. customThe solid obtained
  6. washwas washed with hexane

出典と根拠

ORDレコード
ord-c4844b0198954552a6ae17f7c6d001e8
出典データセット
uspto-grants-2011_03
特許番号
US07902400B2

関連ノート

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