Sodium Iodide → [2-(4-Chlorophenyl)-4-methylthiazol-5-yl]methyltriphenylphosphonium iodide

HRID 602194

反応式

HRID 602194 の反応式
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[I-:20].[Na+].Cl[CH2:23][C:24]1[S:28][C:27]([C:29]2[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=2)=[N:26][C:25]=1[CH3:36]>O1CCCC1>[I-:20].[Cl:35][C:32]1[CH:31]=[CH:30][C:29]([C:27]2[S:28][C:24]([CH2:23][P+:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[C:25]([CH3:36])[N:26]=2)=[CH:34][CH:33]=1

参加物

5

反応物 3

HCID 5238Sodium IodideHCID 11776TriphenylphosphineHCID 27636945-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole

生成物 1

HCID 86615887[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]methyltriphenylphosphonium iodide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Triphenylphosphine (1.15 g, 4.26 mmol) and sodium iodide (580 mg, 3.87 mmol) were added to 5-chloromethyl-2-(4-chlorophenyl)-4-methylthiazole (1.00 g, 3.87 mmol) in tetrahydrofuran (20 mL). The reaction mixture was stirred for 5 hours while being stirred. Subsequently, the crystallized powdery product was collected by filtration and washed with hexane to give 2.43 g (quant.) of the desired compound as a colorless powder.

後処理

  1. stirringwhile being stirred
  2. filtrationSubsequently, the crystallized powdery product was collected by filtration
  3. washwashed with hexane

出典と根拠

ORDレコード
ord-d31d6f1021094d158b4e074d81c7946f
出典データセット
uspto-grants-2011_03
特許番号
US07902367B2

関連ノート

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